Sensitivity, robustness, and identifiability in stochastic chemical kinetics models
نویسندگان
چکیده
منابع مشابه
Sensitivity, robustness, and identifiability in stochastic chemical kinetics models.
We present a novel and simple method to numerically calculate Fisher information matrices for stochastic chemical kinetics models. The linear noise approximation is used to derive model equations and a likelihood function that leads to an efficient computational algorithm. Our approach reduces the problem of calculating the Fisher information matrix to solving a set of ordinary differential equ...
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where k is the rate constant. The stochastic approach to chemical kinetics is concerned with modeling chemical reactions in situations where the assumptions underlying equations of this type break down. In order to illustrate this, suppose that the reaction above is occuring in a drop of water of volume V , which contains only a very small number, say 3, of molecules of I. The kinetic equation ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1015814108